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    Metformin belongs to a group of drugs called the biguanides, which consist of two linked guanidine rings.

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    For centuries people have used French Lilac (Galega officinalis) to treat the symptoms of diabetes mellitus. But it was only in the last century that the active ingredient was isolated and identified. This compound, a single guanidine ring, while itself being too toxic to be used in the long term management of diabetes, led to the development of one of the safest and most widely used of all the antidiabetic medications: metformin.

    Metformin belongs to a group of drugs called the biguanides, which consist of two linked guanidine rings. A

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    But it was only in the last century that the active ingredient was isolated and identified. This compound, a single guanidine ring, while itself being too toxic to be used in the long term management of diabetes, led to the development of one of the safest and most widely used of all the antidiabetic medications: metformin.

    Metformin belongs to a group of drugs called the biguanides, which consist of two linked guanidine rings.

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    ingle guanidine ring, while itself being too toxic to be used in the long term management of diabetes, led to the development of one of the safest and most widely used of all the antidiabetic medications: metformin.

    Metformin belongs to a group of drugs called the biguanides, which consist of two linked guanidine rings.

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    the development of one of the safest and most widely used of all the antidiabetic medications: metformin.

    Metformin belongs to a group of drugs called the biguanides, which consist of two linked guanidine rings.

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    Metformin belongs to a group of drugs called the biguanides, which consist of two linked guanidine rings. Although it has been used to treat diabetes for at least thirty years, it is only now that we are beginning to get an idea of how it works, even though the exact mechanisms of action remain more or less a mystery.

    What we do know, however, is that metformin has a number of different effects on glucose metabolism. These effects lead to improved insulin sensitivity in tissues such as muscle and liver as well as decreased gluconeoge

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